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DIAGNOSTICS IN CLINICAL SETTING
Year : 2018  |  Volume : 4  |  Issue : 2  |  Page : 67-71

Sickle cell anemia: An update on diagnosis, management and prevention strategies


1 Senior Resident, Department of Pathology & Laboratory Medicine, All India Institute of Medical Sciences, Bhubaneswar, India
2 Assistant Professor, Department of Pathology & Laboratory Medicine, All India Institute of Medical Sciences, Bhubaneswar, India

Correspondence Address:
Gaurav Chhabra
Assistant Professor, Pathology & Lab Medicine, AIIMS, Bhubaneswar
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/2395-2113.251444

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Sickle cell anemia is the most common disease entity of all the monogenic disorders. This is an autosomal recessive disorder. HbS polymerization, vaso-occlusion, and hemolytic anemia are central to the pathophysiology of sickle cell disease, they precipitate a cascade of pathologic events, which in turn lead to a wide range of complications. The disease is particularly more prevalent in certain regions of the country like Odisha, Madhya Pradesh, Tamilnadu and has a significant impact on morbidity. Community based approach by providing availability of screening tests, & pre-marital and pre-pregnancy counselling should be initiated to reduce the disease burden in the society.


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