| DIAGNOSTICS IN CLINICAL SETTING |
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| Year : 2018 | Volume
: 4
| Issue : 2 | Page : 67-71 |
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Sickle cell anemia: An update on diagnosis, management and prevention strategies
Shruti Mishra1, Gaurav Chhabra2
1 Senior Resident, Department of Pathology & Laboratory Medicine, All India Institute of Medical Sciences, Bhubaneswar, India
2 Assistant Professor, Department of Pathology & Laboratory Medicine, All India Institute of Medical Sciences, Bhubaneswar, India
Correspondence Address:
Gaurav Chhabra
Assistant Professor, Pathology & Lab Medicine, AIIMS, Bhubaneswar
India
 Source of Support: None, Conflict of Interest: None
DOI: 10.4103/2395-2113.251444
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Sickle cell anemia is the most common disease entity of all the monogenic disorders. This is an autosomal recessive disorder. HbS polymerization, vaso-occlusion, and hemolytic anemia are central to the pathophysiology of sickle cell disease, they precipitate a cascade of pathologic events, which in turn lead to a wide range of complications. The disease is particularly more prevalent in certain regions of the country like Odisha, Madhya Pradesh, Tamilnadu and has a significant impact on morbidity. Community based approach by providing availability of screening tests, & pre-marital and pre-pregnancy counselling should be initiated to reduce the disease burden in the society.
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